About our Research Area

Listeria monocytogenes is an intracellular facultative bacterial pathogen that remains a global challenge to food production and public health, due to its strong association with foodborne transmission and relatively high mortality burden in clinical infection cases. This pathogen can well-adapt to various stress environments and replicate in animal cells as well as in external environment. The move from stress environments to the cytosol requires the interplay of L. monocytogenes factors that promote survival in the gut, bacterial invasion, and phagosomal escape, followed by replication and movement within the cytosol and spread to adjacent cells.